Relationship between ovarian cancer stem cells, epithelial mesenchymal transition and tumour recurrence.

Autor:	Padilla MAA; School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia., Binju M; School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia., Wan G; School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia., Rahmanto YS; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA., Kaur P; School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia., Yu Y; School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Perth, WA 6102, Australia.; Division of Obstetrics & Gynaecology, University of Western Australia Medical School, WA 6009, Australia.
Jazyk:	angličtina
Zdroj:	Cancer drug resistance (Alhambra, Calif.) [Cancer Drug Resist] 2019 Dec 19; Vol. 2 (4), pp. 1127-1135. Date of Electronic Publication: 2019 Dec 19 (Print Publication: 2019).
DOI:	10.20517/cdr.2019.76
Abstrakt:	Investigating the biological processes that occur to enable recurrence and the development of chemoresistance in ovarian cancer is critical to the research and development of improved treatment options for patients. The lethality of ovarian cancer is largely attributed to the recurrence of disease with acquired chemoresistance. Cancer stem cells are likely to be critical in ovarian cancer progression, contributing to tumour malignancy, metastasis and recurrence by persisting in the body despite treatment with anti-cancer drugs. Moreover, cancer stem cells are capable of mediating epithelial-to-mesenchymal transition traits and secrete extracellular vesicles to acquire therapy resistance and disease dissemination. These attributes merit in depth research to provide insight into the biological role of ovarian cancer stem cells in disease progression and chemotherapy response, leading to the development of improved biomarkers and innovative therapeutic approaches. Competing Interests: All authors declare that there are no conflicts of interest. (© The Author(s) 2019.)
Databáze:	MEDLINE
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