Trivalent arsenic impairs the effector response of human CD4 + and CD8 + T cells to influenza A virus ex vivo.

Autor: Freeborn RA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States; Institute for Integrated Toxicology, Michigan State University, East Lansing, MI, 48824, United States., Boss AP; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, United States., Kaiser LM; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, United States., Gardner EM; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, United States., Rockwell CE; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States; Institute for Integrated Toxicology, Michigan State University, East Lansing, MI, 48824, United States; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, 48824, United States; Applied Immunology Center for Education and Research, Michigan State University, East Lansing, MI, 48824, United States. Electronic address: rockwelc@msu.edu.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Jul; Vol. 165, pp. 113122. Date of Electronic Publication: 2022 May 14.
DOI: 10.1016/j.fct.2022.113122
Abstrakt: Arsenic is a persistent environmental contaminant that humans are exposed to primarily through contaminated water supplies. Arsenic has been shown to have numerous immunomodulatory effects, including deleterious effects on T cell function. However, the effect of arsenic on human T cell function in the context of influenza infection remains poorly characterized. The goal of this study was to determine the effects of arsenic on T cell activation and effector function in a human-relevant ex vivo model with influenza challenge. Flow cytometric analysis of T cells following the treatment of primary human peripheral blood mononuclear cells with environmentally relevant concentrations of arsenic trioxide and subsequent challenge with influenza A virus showed reduced viability, alterations in activation, a reduction in the population of memory cells, and reduced effector function evidenced by decreased IFNγ and granzyme B production. Overall, these studies suggest that arsenic impairs the human T cell response to influenza which corroborates epidemiological findings and could have further implications for antiviral immunity and vaccine efficacy.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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