The temporal relationships between sleep disturbance and autonomic dysregulation: A co-twin control study.

Autor: Huang M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Bliwise DL; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA., Shah A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine (Cardiology), School of Medicine, Emory University, Atlanta, GA, USA; Atlanta Veteran Affairs Medical Center, Decatur, GA, USA., Johnson DA; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Clifford GD; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Hall MH; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Krafty RT; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Goldberg J; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Vietnam Era Twin Registry, Seattle Epidemiologic Research and Information Center, US Department of Veterans Affairs, Seattle, WA, USA., Sloan R; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Ko YA; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Da Poian G; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Perez-Alday EA; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Murrah N; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Levantsevych OM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Shallenberger L; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Abdulbaki R; Department of Pathology, Georgia Washington University Hospital, Washington, DC, USA., Vaccarino V; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine (Cardiology), School of Medicine, Emory University, Atlanta, GA, USA. Electronic address: viola.vaccarino@emory.edu.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2022 Sep 01; Vol. 362, pp. 176-182. Date of Electronic Publication: 2022 May 14.
DOI: 10.1016/j.ijcard.2022.05.028
Abstrakt: Introduction: Sleep disturbance is associated with autonomic dysregulation, but the temporal directionality of this relationship remains uncertain. The objective of this study was to evaluate the temporal relationships between objectively measured sleep disturbance and daytime or nighttime autonomic dysregulation in a co-twin control study.
Methods: A total of 68 members (34 pairs) of the Vietnam Era Twin Registry were studied. Twins underwent 7-day in-home actigraphy to derive objective measures of sleep disturbance. Autonomic function indexed by heart rate variability (HRV) was obtained using 7-day ECG monitoring with a wearable patch. Multivariable vector autoregressive models with Granger causality tests were used to examine the temporal directionality of the association between daytime and nighttime HRV and sleep metrics, within twin pairs, using 7-day collected ECG data.
Results: Twins were all male, mostly white (96%), with mean (SD) age of 69 (2) years. Higher daytime HRV across multiple domains was bidirectionally associated with longer total sleep time and lower wake after sleep onset; these temporal dynamics were extended to a window of 48 h. In contrast, there was no association between nighttime HRV and sleep measures in subsequent nights, or between sleep measures from previous nights and subsequent nighttime HRV.
Conclusions: Daytime, but not nighttime, autonomic function indexed by HRV has bidirectional associations with several sleep dimensions. Dysfunctions in autonomic regulation during wakefulness can lead to subsequent shorter sleep duration and worse sleep continuity, and vice versa, and their influence on each other may extend beyond 24 h.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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