Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19 infection?
| Autor: | Ozturk G, Eraslan BZ, Akpinar P, Karamanlioglu Silte D, Ozkan Unlu F, Aktas I |
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| Jazyk: | angličtina |
| Zdroj: | Bratislavske lekarske listy [Bratisl Lek Listy] 2022; Vol. 123 (6), pp. 421-427. |
| DOI: | 10.4149/BLL_2022_065 |
| Abstrakt: | Objectives: This study is aimed to determine the relationship between 25-OH vitamin D levels, inflammatory parameters of neutrophil‑to‑lymphocyte ratio (NLR), platelet‑to‑lymphocyte ratio (PLR), c‑reactive protein (CRP) levels and the disease severity of COVID-19 infection. Background: Inflammation plays a key role in the pathogenesis of COVID-19 while identifying the clinical course and prognosis. The effect of vitamin D deficiency on contribution to inflammation in COVID-19 is unclear. Methods: Based on the classification of the clinical course of COVID-19, the patients were divided into three groups, i.e., with mild (Group 1), moderate (Group 2) and severe/critical cases (Group 3). The 25-OH vitamin D values were defined as deficient, insufficient or normal. Results: There were no statistically significant differences in the distribution rates of 25-OH vitamin D levels (p>0.05) between the groups. Inflammatory parameters in Group 3 were statistically significantly higher as compared to Groups1 and 2 (p<0.05). Multivariate logistic regression analysis revealed that NLR was an independent predictor of disease severity. Conclusion: There is no relationship between the severity of COVID-19 infection and 25-OH vitamin D deficiency. Inflammatory parameters are associated with the disease severity, while NLR is an independent predictor of severe COVID-19. There was no correlation between 25-OH vitamin D and inflammatory markers (Tab. 4, Fig. 1, Ref. 38). |
| Databáze: | MEDLINE |
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