| Autor: |
Oros-Pantoja R; Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico., Córdoba-Adaya JC; Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico., Torres-García E; Laboratorio de Dosimetría y Simulación Monte Carlo, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico., Morales-Avila E; Laboratorio de Investigación en Farmacia, Facultad de Química, Universidad Autónoma del Estado de México, Toluca, Mexico., Aranda-Lara L; Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico., Santillán-Benítez JG; Laboratorio de Investigación en Farmacia, Facultad de Química, Universidad Autónoma del Estado de México, Toluca, Mexico., Sánchez-Holguín M; Departamento de Medicina Nuclear, Centro Oncológico Estatal-ISSEMyM, Toluca, Mexico., Hernández-Herrera NO; Departamento de Medicina Nuclear, Centro Oncológico Estatal-ISSEMyM, Toluca, Mexico., Otero G; Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico., Isaac-Olivé K; Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico. |
| Abstrakt: |
Although liposomal doxorubicin (LPD) is widely used for cancer treatment, knowledge concerning the toxicity induced by this drug in healthy organs and tissues is limited. LPD-induced toxicity studies relative to free doxorubicin (DOX) have focused on cardiotoxicity in tumor-bearing animals. On the other hand, the results on DOX-induced cardiotoxicity depending on gender are controversial. One of the manifestations of toxicity is tissue inflammation. 67 Ga-citrate has been used for decades to assess inflammation in various pathologies. In this work, the ex vivo biodistribution of 67 Ga-citrate is used to evaluate induced multi-organ toxicity in healthy 10-week-old male and female CD1 mice treated for 5 weeks with LPD. Toxicity in males, determined by 67 Ga-citrate, was evident only in the target organs of liposomes (spleen, liver, kidneys, and lungs); the average weight loss was 11% and mortality was 14%. In female mice, 67 Ga-citrate revealed a cytotoxic effect in practically all organs, the average weight loss was 37%, and the mortality after the last dose of LPD was 66%. These results confirm the usefulness of 67 Ga-citrate and the importance of stratifying by sex in the toxicological evaluation of drugs. |
