Organocatalyzed Modular Synthesis of Polycyclic Dihydropyridines and Pyridines through Sulfamate Linchpin.
| Autor: | Bhajammanavar V; Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India., Sureshbabu P; Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India., Kesava Reddy M; Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India., Baidya M; Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry, an Asian journal [Chem Asian J] 2022 Aug 01; Vol. 17 (15), pp. e202200400. Date of Electronic Publication: 2022 Jun 07. |
| DOI: | 10.1002/asia.202200400 |
| Abstrakt: | The cascade annulation between alkylidene malononitriles and cyclic sulfamidate imines has been controlled by leveraging the sulfamate functionality under organocatalysis, which allows selective access to polycyclic and densely functionalized dihydropyridines and pyridines in high yields. The protocol is scalable and shows broad substrate scope. The products were also engaged in the preparation of tetracyclic pyridopyrimidines, showcasing the synthetic versatility. (© 2022 Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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