Molecular docking analysis of glycogen phosphorylase with inhibitors from Cissampelos pareira Linn.

Autor:	Chandrashekar K; Department of Anatomy, AIIMS, Nagpur 441108, India., Rajagopal P; Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India., Jh SF; Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India., Radhakrishnan S; Department of Biochemistry, Karapaga Vinayaga Institute of Medical and Dental science, Madhuranthagam- 603308, Tamil Nadu, India., Krishnan Muthaiah VP; Department of Rehabilitation Science, School of Public Health and Health professions, 633 Kimball, Buffalo NY, 14214-3079., Sontakke BR; Department of Anatomy, AIIMS, Nagpur 441108, India., Deshmukh VR; Department of Anatomy, AIIMS, Nagpur 441108, India., Periyasamy V; DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu, India., Muthiyan GG; Department of Anatomy, AIIMS, Nagpur 441108, India., Tarnekar AM; Department of Anatomy, AIIMS, Nagpur 441108, India., Gugapriya TS; Department of Anatomy, AIIMS, Nagpur 441108, India., Laxman PA; Department of Physiology, AIIMS, Nagpur 441108, India., Tripathi SC; Department of Biochemistry, AIIMS, Nagpur 441108, India., Jayaraman S; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
Jazyk:	angličtina
Zdroj:	Bioinformation [Bioinformation] 2021 Oct 31; Vol. 17 (10), pp. 866-869. Date of Electronic Publication: 2021 Oct 31 (Print Publication: 2021).
DOI:	10.6026/97320630017866
Abstrakt:	Cissampelos pareira Linn. is a climbing herb known in Indian traditional medicine as laghupatha. It belongs to the Menispermaceae family. The enzyme glycogen phosphorylase (GP) is a promising target for the treatment of type-2 diabetes (T2DM). A variety of natural product inhibitors with both pharmaceutical and nutraceutical potential have been reported in the search for powerful, selective and drug-like GP inhibitors that could lead to hypoglycemic medicines. Therefore, it is of interest to document the molecular docking analysis data of glycogen phosphorylase with compounds from Cissampelos pareira Linn. We report the optimal binding features of 4 compounds namely Trans-N-feruloyltyramine, Coclaurine, Magnoflorine, and Curine with the target protein for further consideration in the context of T2DM. Competing Interests: No conflict of interest from any of the authors. (© 2021 Biomedical Informatics.)
Databáze:	MEDLINE
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