Comparison of blood parameters between periodontitis patients and healthy participants: A cross-sectional hematological study.

Autor:	Bhattacharya HS; Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India., Srivastava R; Department of Periodontology and Implantology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India., Gummaluri SS; Department of Periodontology and Implantology, Sree Sai Dental College and Research Institute, Srikakulam, Andhra Pradesh, India., Agarwal MC; Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India., Bhattacharya P; Department of Orthodontics and Dentofacial Orthopaedics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India., Astekar MS; Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	Journal of oral and maxillofacial pathology : JOMFP [J Oral Maxillofac Pathol] 2022 Jan-Mar; Vol. 26 (1), pp. 77-81. Date of Electronic Publication: 2022 Mar 31.
DOI:	10.4103/jomfp.jomfp_349_21
Abstrakt:	Background: Bacteria and their products involved in periodontitis evoke an immunoinflammatory response in the host tissue. Inflammatory diseases, such as periodontitis, are often not just a local event, but may have systemic ramifications, including elevations in the numbers of circulating leukocytes, acute-phase proteins and oxidative stress markers. It is now emerging that also erythrocytes are affected by chronic inflammatory diseases. This phenomenon, named "anemia of inflammation," is not caused by marrow deficiencies or other diseases. The present study aimed to assess whether there was any relation between chronic periodontitis and hematological parameters. Materials and Methods: A total of 80 patients were included in the study and were divided into the healthy and periodontitis groups. Blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes, platelets, red blood cell (RBC) distribution width (RDW), mean corpuscular volume (MCV), platelet count and neutrophil-leukocyte ratio (NLR). Further, the values were gathered and subjected to statistical analysis. Unpaired t -test was performed to assess the statistical significance between the groups and P < 0.05 and < 0.001 were considered to be statistically significant. Results: Results show statistically significant difference seen in leukocytes, lymphocytes, RDW, MCV, platelet count and NLR which was higher in patients with periodontitis, all other parameters are nonsignificant. Conclusion: Thus, within limitations, it can be concluded that increased levels of leukocytes, lymphocytes, RDW, MCV, platelet count and NLR depict the inflammatory state and destructive nature of periodontitis. Competing Interests: There are no conflicts of interest. (Copyright: © 2022 Journal of Oral and Maxillofacial Pathology.)
Databáze:	MEDLINE
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