Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions.

Autor: Bruggeman AAE; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands., Aberson N; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands., Kappelhof M; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Dutra BG; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Hoving JW; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands., Brouwer J; Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Tolhuisen ML; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Terreros NA; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Konduri PR; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Boodt N; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., Roos YBWEM; Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., van Zwam WH; Department of Radiology and Nuclear Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Bokkers R; Department of Radiology and Nuclear Medicine, University Medical Center Groningen, Groningen, The Netherlands., Martens J; Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands., Marquering HA; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Emmer BJ; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands. b.j.emmer@amsterdamumc.nl., Majoie CBLM; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Room G1-240, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2022 Sep; Vol. 64 (9), pp. 1857-1867. Date of Electronic Publication: 2022 May 16.
DOI: 10.1007/s00234-022-02971-4
Abstrakt: Purpose: We aimed to study the association of non-contrast CT (NCCT) thrombus density with procedural and clinical outcomes in patients with acute ischemic stroke who underwent endovascular treatment (EVT). Since thrombus density is associated with thrombus location, we focused on M1 occlusions only.
Methods: Patients with available thin-slice (< 2.5 mm) NCCT were included from a nationwide registry. Regression models were used to assess the relation between thrombus density (per Hounsfield unit [HU]) and the following outcomes. For reperfusion grade, adjusted common odds ratios (acOR) indicated a 1-step shift towards improved outcome per HU increase in thrombus density. For the binary outcomes of first-pass reperfusion (first-pass extended thrombolysis in cerebral infarction [eTICI] 2C-3, FPR), functional independence [90-day modified Rankin Scale (mRS) score of 0-2] and mortality), aORs were reported. Adjusted β coefficients (aβ) were reported for 24-h NIHSS and procedure duration in minutes. Outcome differences between first-line treatment devices (stent retriever versus aspiration) were assessed with interaction terms.
Results: In 566 patients with M1 occlusions, thrombus density was not associated with reperfusion (acOR 1.01, 95% CI 0.99-1.02), FPR (aOR 1.01, 95% CI 0.99-1.03), mortality (aOR 0.98, 95% CI 0.95-1.00), 24-h NIHSS (aβ - 0.7%, 95% CI - 1.4-0.2), or procedure duration (aβ 0.27, 95% CI - 0.05-0.58). In multivariable analysis, thrombus density was associated with functional independence (aOR 1.02, 95% CI 1.00-1.05). No interaction was found between thrombus density and first-line treatment device for any outcome.
Conclusion: In patients with M1 occlusions, thrombus density was not clearly associated with procedural and clinical outcomes after EVT.
(© 2022. The Author(s).)
Databáze: MEDLINE
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