Humoral immunity at the brain borders in homeostasis.

Autor: Posner DA; Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK., Lee CY; Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK., Portet A; Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK., Clatworthy MR; Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK. Electronic address: mrc38@cam.ac.uk.
Jazyk: angličtina
Zdroj: Current opinion in immunology [Curr Opin Immunol] 2022 Jun; Vol. 76, pp. 102188. Date of Electronic Publication: 2022 May 12.
DOI: 10.1016/j.coi.2022.102188
Abstrakt: The meninges encase the brain and spinal cord and house a variety of immune cells, including developing and mature B cells, and antibody-secreting plasma cells. In homeostasis, these cells localize around the dural venous sinuses, providing a defense 'zone' to protect the brain and spinal cord from blood-borne pathogens. Dural plasma cells predominantly secrete IgA antibodies, and some originate from the gastrointestinal tract, with the number and antibody isotype shaped by the gut microbiome. For developing B cells arriving from the adjacent bone marrow, the dura provides a site to tolerize against central nervous system antigens. In this review, we will discuss our current understanding of meningeal humoral immunity in homeostasis.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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