Association between intervertebral disc degeneration and Behçet's disease.

Autor: Manav V; Department of Dermatology, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey., İlhan D; Department of Dermatology, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey., Mercan H; Department of Biochemistry, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey., Kılıç A; Department of Physical Medicine and Rehabilitation, Istanbul Physical and Rehabilitation Medicine Training and Research Hospital, İstanbul, Turkey., Polat AK; Department of Dermatology, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey., Aksu AEK; Department of Dermatology, İstanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
Jazyk: angličtina
Zdroj: Dermatologic therapy [Dermatol Ther] 2022 Jul; Vol. 35 (7), pp. e15585. Date of Electronic Publication: 2022 May 23.
DOI: 10.1111/dth.15585
Abstrakt: Behçet's disease (BD) is a chronic systemic vasculitis with a wide range of clinical findings. It has both autoinflammatory and autoimmune features and manifests with recurrent inflammatory attacks involving the innate immune system. Recently, autoinflammation has started to take place in the pathogenesis of intervertebral disc degeneration. The aim of this study is to evaluate the relationship between intervertebral disc degeneration and BD. We evaluated patients with BD who suffered neck or low back pain in the last 1 year. Eighty four patients underwent musculoskeletal system examination with MRI imaging of the cervical and lumbar vertebrae, and serum levels of IL6, IL8, and TNF-α were determined. The mean age was 47.7 ± 11.5 (range 20-68) years. Cervical and/or lumbar herniation was detected in the MRI imaging of 65 (77.3%) out of 84 patients. The mean IL8 levels of the group with pain and disc herniation and the group with pain and bulging were statistically significantly higher than the other groups (p = 0.007; p = 0.045, respectively). Chronic inflammation in BD may cause disc degeneration and radicular pain to begin and progress earlier in patients.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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