An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment.

Autor: Veres T; Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, Hungary., Voniatis C; Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, Hungary.; Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1082 Budapest, Hungary., Molnár K; Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, Hungary., Nesztor D; Department of Food Engineering, University of Szeged, 6725 Szeged, Hungary., Fehér D; Heart and Vascular Centre, Department of Surgical Research and Techniques, Semmelweis University, 1122 Budapest, Hungary., Ferencz A; Heart and Vascular Centre, Department of Surgical Research and Techniques, Semmelweis University, 1122 Budapest, Hungary., Gresits I; Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary., Thuróczy G; NRIRR 'Frédéric Joliot-Curie' National Research Institute for Radiobiology and Radiohygiene, 1221 Budapest, Hungary., Márkus BG; Stavropoulos Center for Complex Quantum Matter, Department of Physics and Astronomy, University of Notre Dame, Notre Dame, IN 46556, USA.; Institute of Physics, Budapest University of Technology and Economics, 1521 Budapest, Hungary.; Wigner Research Centre for Physics Economics, 1121 Budapest, Hungary., Simon F; Institute of Physics, Budapest University of Technology and Economics, 1521 Budapest, Hungary.; Wigner Research Centre for Physics Economics, 1121 Budapest, Hungary., Nemes NM; Grupo de Física de Materiales Complejos (GFMC), Departamento de Física de Materiales, Universidad Complutense de Madrid, 28040 Madrid, Spain., García-Hernández M; Grupo de Física de Materiales Complejos (GFMC), Departamento de Física de Materiales, Universidad Complutense de Madrid, 28040 Madrid, Spain., Reiniger L; Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Horváth I; Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary., Máthé D; Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.; Hungarian Center of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Semmelweis University Site, 1094 Budapest, Hungary., Szigeti K; Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary., Tombácz E; Department of Food Engineering, University of Szeged, 6725 Szeged, Hungary.; Soós Ernő Water Technology Research and Development Center, University of Pannonia, 8800 Nagykanizsa, Hungary., Jedlovszky-Hajdu A; Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, 1089 Budapest, Hungary.
Jazyk: angličtina
Zdroj: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Apr 26; Vol. 12 (9). Date of Electronic Publication: 2022 Apr 26.
DOI: 10.3390/nano12091476
Abstrakt: When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 °C (from 37 °C to 42 °C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation.
Databáze: MEDLINE
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