Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle.

Autor: Prihatiningsih MC; Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl. Grafika No. 2, Yogyakarta 55281, Indonesia.; Polytechnic Institute of Nuclear Technology, National Research and Innovation Agency, Jl. Babarsari POB 6101 Ykbb, Yogyakarta 55281, Indonesia., Ariyanto T; Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl. Grafika No. 2, Yogyakarta 55281, Indonesia., Putra EGR; Center for Science and Technology of Advanced Materials, National Research and Innovation Agency, Kawasan Puspiptek Serpong, Banten 15314, Indonesia., Susilo VY; Research and Technology Center for Radioisotope and Radiopharmaceutical, National Research and Innovation Agency, Kawasan Puspiptek Serpong, Banten 15314, Indonesia., Mahendra I; Research and Technology Center for Applied Nuclear, National Research and Innovation Agency, Tamansari 71, Bandung 40132, West Java, Indonesia., Prasetyo I; Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl. Grafika No. 2, Yogyakarta 55281, Indonesia.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2022 Apr 18; Vol. 7 (16), pp. 13494-13506. Date of Electronic Publication: 2022 Apr 18 (Print Publication: 2022).
DOI: 10.1021/acsomega.1c06492
Abstrakt: There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims to prepare a theranostic cancer vehicle based on porous silica nanoparticles (PSN) with controllable nanoparticle size, supporting targeting properties, and biocompatible. The synthesis method combined the Stöber process and liquid crystal templating using a dispersant and pore expander. Triethanolamine (TEA) and Pluronic F-127 were combined as a steric stabilizer and dispersing agent, while n -hexane was used as a pore expander. The amine functionalization was carried out using the 3-aminopropyl-triethoxysilane solution. Furthermore, radiolabeling of PSN using Iodine-131 and iodogen as oxidizing agents was carried out. The results showed that the best achievable PSN size was 100-150 nm with a polydispersity index of 0.24 using TEA-Pluronic F-127. The functionalization results did not significantly affect the radioiodination result. Radiochemical purity (RCP) values up to 95% were obtained in the radioiodination, while the labeled compounds were relatively stable with 12 mCi radioactivity, indicating the absence of radiolysis. The synthesized PSN was not toxic to normal cell samples up to a concentration of 150 μg/mL for PSN and 170 μg/mL for PSN-NH 2 . The cellular uptake testing results of the PSN- 131 I in cancer cell samples showed promising uptake ability.
Competing Interests: The authors declare no competing financial interest.
(© 2022 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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