l-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety via sustainable sonochemical approach.
| Autor: | Ibrahim HM; Chemistry Department, Faculty of Science, Fayoum University P. O. Box 63514 Fayoum Egypt hmi00@fayoum.edu.eg hamadaaldeb@yahoo.com +965-248-164-82 +965-55216585., Ahmed Arafa WA; Chemistry Department, Faculty of Science, Fayoum University P. O. Box 63514 Fayoum Egypt hmi00@fayoum.edu.eg hamadaaldeb@yahoo.com +965-248-164-82 +965-55216585.; Chemistry Department, College of Science, Jouf University P. O. Box 2014 Sakaka Aljouf Kingdom of Saudi Arabia., Behbehani H; Chemistry Department, Faculty of Science, Kuwait University P. O. Box 5969 Safat 13060 Kuwait drhaider.b@gmail.com +965-248-164-82 +965-55888646. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2018 Nov 08; Vol. 8 (66), pp. 37606-37617. Date of Electronic Publication: 2018 Nov 08 (Print Publication: 2018). |
| DOI: | 10.1039/c8ra07013j |
| Abstrakt: | The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established via the reaction of N -(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification. Competing Interests: The authors declare that they have no competing interests. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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