Exchange dynamics between amphiphilic block copolymers and lipidic membranes through hydrophobic pyrene probe transfer.

Autor: Bravo-Anaya LM; Univ. Grenoble Alpes, LRP F-38000 Grenoble France monik_ayanami@hotmail.com yahya.rharbi@univ-grenoble-alpes.fr.; CNRS, LRP F-38000 Grenoble France.; Universidad de Guadalajara, Departamento de Ingeniería Química Blvd. M. García Barragán #1451 C.P. 44430 Guadalajara Jalisco Mexico., Gómez GL; Universidad de Guadalajara, Departamento de Ingeniería Química Blvd. M. García Barragán #1451 C.P. 44430 Guadalajara Jalisco Mexico., Figueroa-Ochoa E; Universidad de Guadalajara, Departamento de Química Blvd. M. García Barragán #1451 C.P. 44430 Guadalajara Jalisco Mexico., Ramos FC; Universidad de Guadalajara, CUTonalá, Departamento de Ingenierías Nuevo Periférico #555 Ejido San José Tatepozco C.P. 45425 Tonalá Jalisco Mexico., Armando Soltero Martínez JF; Universidad de Guadalajara, Departamento de Ingeniería Química Blvd. M. García Barragán #1451 C.P. 44430 Guadalajara Jalisco Mexico., Rharbi Y; Univ. Grenoble Alpes, LRP F-38000 Grenoble France monik_ayanami@hotmail.com yahya.rharbi@univ-grenoble-alpes.fr.; CNRS, LRP F-38000 Grenoble France.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2018 Nov 26; Vol. 8 (69), pp. 39444-39454. Date of Electronic Publication: 2018 Nov 26 (Print Publication: 2018).
DOI: 10.1039/c8ra08903e
Abstrakt: Vectorization has experienced significant development over the last few years and has been used to control the distribution of active ingredients to a target by their association with a vector. However, controlled drug delivery suffers from "burst release" as the drugs are released before the targeted site. Very few studies have examined the collective mechanisms of fission-fusion on micelles in the transport and expulsion of active ingredients. Endocytosis and exocytosis of cells are examples of fusion and fission in biological matter. Understanding these dynamics becomes crucial for the design and the control of new materials and new processes effective in controlled drug delivery. In this work, a study of the exchange dynamics between amphiphilic block copolymers and lipid membranes for vectorization of hydrophobic molecules using a fluorescence technique is presented. A highly hydrophobic alkylated pyrene, PyC 18 , is used as a fluorescent probe that can be exchanged between amphiphilic block copolymer micelles and liposomes via different mechanisms. It is demonstrated that the exchange dynamics evaluated for different liposome concentrations is a collective mechanism characterized by having two rate constants.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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