Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction.

Autor:	Khumalo MF; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Akpan ED; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Chinthakindi PK; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Brasil EM; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Rajbongshi KK; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Makatini MM; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand PO Witz 2050 Johannesburg South Africa., Govender T; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Kruger HG; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Naicker T; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za., Arvidsson PI; Catalysis and Peptide Research Unit, University of KwaZulu Natal Durban South Africa 4001 Naickert1@ukzn.ac.za.; Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet Stockholm Sweden per.arvidsson@scilifelab.se.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2018 Nov 07; Vol. 8 (65), pp. 37503-37507. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).
DOI:	10.1039/c8ra07627h
Abstrakt:	Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of β-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The β-aminoethane sulfonamides were obtained through sequential Michael addition of amines to α,β-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(vi) fluoride exchange (SuFEx) reaction with amines at the S-F bond. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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