Short-term outcomes of patients with chronic liver disease hospitalised with COVID-19.

Autor: Grgurevic I; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Lucijanić M; School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Hematology, University Hospital Dubrava, Zagreb, Croatia., Pastrovic F; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Barisic Jaman M; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Tjesic Drinkovic I; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Zelenika M; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Milosevic M; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Medic B; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Kardum D; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia., Bokun T; Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Luksic I; School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia., Piskac Zivkovic N; Department of Pulmonology, University Hospital Dubrava, Zagreb, Croatia., Keres T; Intensive Care Unit, Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia., Grabovac V; Intensive Care Unit, Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia.; Department of Emergency Medicine, University Hospital Dubrava, Zagreb, Croatia., Persec J; Intensive Care Unit, Department of Anestesiology, Renimatology and Intensive Care, University Hospital Dubrava, Zagreb, Croatia.; School of Dental Medicine, University of Zagreb, Zagreb, Croatia., Barsic B; School of Medicine, University of Zagreb, Zagreb, Croatia.; Intensive Care Unit, Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia.
Jazyk: angličtina
Zdroj: Internal medicine journal [Intern Med J] 2022 Nov; Vol. 52 (11), pp. 1891-1899. Date of Electronic Publication: 2022 Aug 31.
DOI: 10.1111/imj.15817
Abstrakt: Background: Patients with chronic liver disease (CLD) might have an aggravated course after acquisition of coronavirus disease 2019 (COVID-19).
Aims: To analyse the outcomes of patients with CLD who were hospitalised due to COVID-19.
Methods: The medical records of 4014 patients hospitalised because of COVID-19 in a regional referral hospital over a 12-month period were analysed. Patients with CLD were identified based on discharge diagnoses according to the International Classification of Diseases-10th Revision. Patients were followed for 30 days from admission and their outcomes (intensive care unit (ICU) admission, mechanical ventilation (MV) or death) were analysed.
Results: Of the 4014 patients, 110 (2.7%) had CLD and 49 (1.2%) had cirrhosis. The median age of CLD patients was 67.5 years, 79 (71.8%) were males, 224 (23.5%) were obese, 56 (50.9%) reported alcohol abuse, 24 (21.8%) had non-alcoholic fatty liver disease, 11 (10%) had viral hepatitis and 98 (89.1%) had pneumonia. The median length of hospitalisation was 12 days; 32 (29.1%) patients required ICU admission and 23 (20.9%) patients required MV, while 43 (39.1%) died. In univariate analysis, patients with cirrhosis (45% vs 73%, hazard ratio (HR) = 2.95; P < 0.001), but not those with non-cirrhotic CLD (74% vs 73%; P > 0.05), experienced worse 30-day survival when compared with age, sex and COVID-19 duration-matched cohorts. In a logistic regression analysis conducted on the overall and matched cohorts, liver cirrhosis, but not CLD, predicted inferior survival independently of age, comorbidities and severity of COVID-19, with a fourfold higher adjusted risk of 30-day mortality.
Conclusion: Cirrhosis is independently associated with higher 30-day mortality of hospitalised patients with COVID-19.
(© 2022 Royal Australasian College of Physicians.)
Databáze: MEDLINE
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