Systematic review of preclinical studies about effects of Coriandrum sativum L. on inflammatory mediators.

Autor: Malek Mahdavi A; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. aidamalek@gmail.com.; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. aidamalek@gmail.com.; Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. aidamalek@gmail.com., Javadivala Z; Department of Health Education and Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2022 Aug; Vol. 30 (4), pp. 1131-1141. Date of Electronic Publication: 2022 May 12.
DOI: 10.1007/s10787-022-01000-3
Abstrakt: This study is designed to systematically review the accessible researches regarding influence of Coriandrum sativum L. on inflammatory mediators including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Databases Scopus, PubMed, WOS, ProQuest, and a Google Scholar were searched until February 2022 and search alerts were turned on to find papers published following the primary search. There was not any restriction in language and/or date. No human study was gained; thus, animal and in vitro researches were considered. The references of related papers were reviewed to access plausible researches. Twenty-four papers were entered in review. Inflammatory factors IL-1β, IL-6, and TNF-α considerably had a descending direction following C. sativum consumption. In other words, the pooled direction of influences was consistently lower for inflammatory mediators in 7 of 9 in vitro and 10 of 16 animal investigations. These results demonstrated the potential of C. sativum in reducing IL-1β, IL-6, and TNF-α. C. sativum is hopeful but not yet a confirmed natural ingredient to reduce systemic inflammation in subjects with inflammation-prone disorders. Additional investigations are required to concentrate on assessing the impact of C. sativum on inflammatory factors that are not exceedingly fluctuating and the clinical consequences of inflammation-linked diseases.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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