Clinical implications of lipid peroxides levels in plasma and tumor tissue in breast cancer patients.

Autor: Scandolara TB; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., da Silva JC; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Alves FM; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Malanowski J; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., de Oliveira ST; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Maito VT; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil., Rech D; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil; Francisco Beltrão Cancer Hospital, Francisco Beltrão, PR, Brazil., Panis C; Laboratory of Tumor Biology, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, PR, Brazil. Electronic address: carolpanis@hotmail.com., Bonvicino C; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Brazilian National Cancer Institute - INCA, Rio de Janeiro, RJ, Brazil.
Jazyk: angličtina
Zdroj: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2022 Aug; Vol. 161, pp. 106639. Date of Electronic Publication: 2022 May 10.
DOI: 10.1016/j.prostaglandins.2022.106639
Abstrakt: Oxidative stress can promote the oxidation of lipoproteins and polyunsaturated fatty acids present in cell membranes; an event known as lipid peroxidation (LPO). LPO has been associated with carcinogenesis and cancer progression, however, its meaning concerning the clinicopathological aspects of human breast cancer is not clear. This study investigated LPO profiles in tumor and plasma samples from breast cancer patients (n = 140) considering their clinicopathological features (age at diagnosis, menopausal status, body mass index, tumor histological grade, tumor size, ki-67 proliferation index, presence of metastasis, chemotherapy response, the molecular subtype of cancer and overall survival status). LPO levels were estimated by tert-butyl hydroperoxide-initiated chemiluminescence. High LPO levels were found regarding poor prognosis parameters as young age at diagnosis (p = 0.006 in tissue), premenopausal patients (p = 0.012 in tissue), high-grade tumors (p = 0.010 in tissue and p = 0.002 in plasma), metastatic disease (p = 0.046 in tissue), chemoresistant tumors (p = 0.041 in tissue), disease relapse (p = 0.018 in tissue and p = 0.009 in plasma) and overall survival status (p = 0.001 in plasma). Our findings point out the clinical meaning of LPO and highlight it as an oxidative stress event linked to poor prognosis and disease aggressiveness in breast cancer patients.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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