| Autor: |
Avilés Martínez MC; Department of Internal Medicine, Albacete University Hospital, Albacete, Spain., Alfaro Martínez JJ; Department of Endocrinology and Nutrition, Albacete University Hospital, Albacete, Spain., Blanch Sancho JJ; Infectious Diseases Unit, Department of Internal Medicine, Albacete University Hospital, Albacete, Spain., Solís García Del Pozo J; Infectious Diseases Unit, Department of Internal Medicine, Albacete University Hospital, Albacete, Spain. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of chemotherapy (Florence, Italy) [J Chemother] 2022 Nov; Vol. 34 (7), pp. 419-426. Date of Electronic Publication: 2022 May 13. |
| DOI: |
10.1080/1120009X.2022.2073160 |
| Abstrakt: |
Ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA) are new possibilities of antimicrobial treatment that combined a β-lactam with a β-lactamase inhibitor. The United States (US) and European regulatory agencies approved their clinical use in adults with complicated intra-abdominal infections. This study aims to know if one of the two antibiotics obtain better efficacy in adults with complicated intra-abdominal infections and by specific pathogens such as P. aeruginosa or E. coli. A search of all trials in MEDLINE, Scopus, and Web of Science comparing a C/T or CZA based antimicrobial regimen with other treatments in patients with intraabdominal infections until August 2021 was performed. To make indirect comparisons, we used a frequentist approach using the R package netmeta.The effects have been expressed through the relative risk (RR) with its confidence interval. Considering the clinical cure and failure rates between the different trial populations (mMITT, CE, ME) and the mortality at the end of the study, we have not found significant differences between CZA and C/T. In the case of Pseudomonas , the RR of treatment failure between these two antibiotics is 1 (95% CI 0.55-1.18). In the case of E. Coli , although it seems that CZA would have a worse result than C/T, differences did not reach statistical significance (RR1.06; 95% CI 0.9-1.14). In conclusion, we have not found statistically significant differences between ceftolozane-tazobactam and ceftazidime-avibactam in treating cIAI. In regards to E. Coli , our results do not reach significance, but it would be possible that C/T and meropenem had better results than CZA. Perhaps new trials would allow a better profile of the role in different types of patients or infections caused by specific microorganisms in the future. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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