Objective measures of reward sensitivity and motivation in people with high v. low anhedonia.

Autor:	Slaney C; Faculty of Life Sciences, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK.; School of Psychological Science, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Perkins AM; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK., Davis R; Department of Psychology, Goldsmiths, University of London, London SE14 6NW, UK., Penton-Voak I; School of Psychological Science, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.; National Institute for Health Research Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK., Munafò MR; School of Psychological Science, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.; National Institute for Health Research Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK., Houghton CJ; Department of Computer Science, Faculty of Engineering, University of Bristol, Bristol BS8 1UB, UK., Robinson ESJ; Faculty of Life Sciences, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2023 Jul; Vol. 53 (10), pp. 4324-4332. Date of Electronic Publication: 2022 May 12.
DOI:	10.1017/S0033291722001052
Abstrakt:	Background: Anhedonia - a diminished interest or pleasure in activities - is a core self-reported symptom of depression which is poorly understood and often resistant to conventional antidepressants. This symptom may occur due to dysfunction in one or more sub-components of reward processing: motivation, consummatory experience and/or learning. However, the precise impairments remain elusive. Dissociating these components (ideally, using cross-species measures) and relating them to the subjective experience of anhedonia is critical as it may benefit fundamental biology research and novel drug development. Methods: Using a battery of behavioural tasks based on rodent assays, we examined reward motivation (Joystick-Operated Runway Task, JORT; and Effort-Expenditure for Rewards Task, EEfRT) and reward sensitivity (Sweet Taste Test) in a non-clinical population who scored high ( N = 32) or low ( N = 34) on an anhedonia questionnaire (Snaith-Hamilton Pleasure Scale). Results: Compared to the low anhedonia group, the high anhedonia group displayed marginal impairments in effort-based decision-making (EEfRT) and reduced reward sensitivity (Sweet Taste Test). However, we found no evidence of a difference between groups in physical effort exerted for reward (JORT). Interestingly, whilst the EEfRT and Sweet Taste Test correlated with anhedonia measures, they did not correlate with each other. This poses the question of whether there are subgroups within anhedonia; however, further work is required to directly test this hypothesis. Conclusions: Our findings suggest that anhedonia is a heterogeneous symptom associated with impairments in reward sensitivity and effort-based decision-making.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu