Is it possible to stage schizophrenia? A systematic review.

Autor: Martínez-Cao C; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain., de la Fuente-Tomás L; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., García-Fernández A; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain., González-Blanco L; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., Sáiz PA; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., Garcia-Portilla MP; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain. albert@uniovi.es.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. albert@uniovi.es.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain. albert@uniovi.es.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. albert@uniovi.es.; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain. albert@uniovi.es., Bobes J; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2022 May 11; Vol. 12 (1), pp. 197. Date of Electronic Publication: 2022 May 11.
DOI: 10.1038/s41398-022-01889-y
Abstrakt: Introduction: A staging model is a clinical tool used to define the development of a disease over time. In schizophrenia, authors have proposed different theoretical staging models of increasing complexity. Therefore, the aims of our study were to provide an updated and critical view of the proposed clinical staging models for schizophrenia and to review the empirical data that support them.
Methods: Systematic literature review following PRISMA guidelines. From the PubMed database and backward reference search, a total of 141 records were retrieved, but only 20 were selected according to the inclusion criteria: (a) available in English; (b) participants with schizophrenia ≥ 18 years; and (c) theoretical and empirical research studies intended to develop, validate, and/or improve staging models of schizophrenia.
Results: Different clinical staging models for schizophrenia were identified, information about the proposed stages was tabulated and presented in the Results section (Tables 1, 2). Most of which include neuroimaging, functioning, and psychopathology, but only two models add objective biomarkers and none include patient point of view. However, few models have been psychometrically tested or used small samples and thus have been validated only partially. In addition, five studies proposed therapeutic interventions according to the stage of the disorder from a theoretical point of view.
Discussion: In conclusion, it is possible to stage schizophrenia, but the models developed have several limitations. Empirical validation and inclusion of more specific biomarkers and measures of other life areas affected by schizophrenia could help in the development of more valid models.
(© 2022. The Author(s).)
Databáze: MEDLINE
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