Roux-en-Y Gastric Bypass as a Treatment for Hepatic Iron Overload: An Exploratory Study.

Autor: de Jesus RN; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Callejas GH; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., David Mendonça Chaim F; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Antonio Gestic M; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Pimentel Utrini M; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Callejas-Neto F; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Adami Chaim E; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil., Cazzo E; Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil. notrevezzo@yahoo.com.br.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2022 Jul; Vol. 32 (7), pp. 2438-2444. Date of Electronic Publication: 2022 May 11.
DOI: 10.1007/s11695-022-06103-y
Abstrakt: Background: Excess bodily iron content is commonly associated with obesity and metabolic associated medical conditions and is thought to lead to cardiovascular disease. The effect of Roux-en-Y gastric bypass (RYGB) on hepatic iron overload remains to be determined.
Objective: To assess the evolution of histologically proven hepatic iron overload after RYGB.
Methods: This is an exploratory historical cohort study in which 42 individuals who underwent RYGB, and then a second surgical procedure had paired liver biopsies collected. Hepatic iron overload and NAFLD features were assessed through histopathological examination. Biochemical iron metabolism parameters were also assessed.
Results: The mean age at RYGB was 47 ± 10.2 years and 92.9% were female. The average time elapsed between RYGB and the second surgical procedure was 20.6 ± 15.4 months. The mean percentage of total weight loss between the two procedures was 26.7 ± 9.4%. Significant reductions in ferritin (220.8 ± 202.9 vs. 101.6 ± 116.7 ng/mL; p = 0.006), hemoglobin (13.7 ± 1.8 vs. 12.1 ± 2.6 g/dL; p = 0.01), and red blood cell count (4.7 ± 0.7 vs. 4.3 ± 0.5 10 6 /mm 3 ; p = 0.003) were observed, as well as reductions in the frequencies of steatosis (83.3% vs. 23.8%; p < 0.0001) and steatohepatitis (52.4% vs. 11.9%; p < 0.0001). The frequency of hepatic iron overload significantly decreased from 16.7 to 2.4% (p = 0.03).
Conclusion: RYGB led to a significant decrease in hepatic iron overload, emerging as a possible therapeutical tool for this condition in individuals with obesity and dysmetabolic iron overload syndrome.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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