Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2.

Autor: Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Dias Loiola LM; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark.; Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo, 13083-970, Brazil., Issmail L; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, 04103, Germany., Uhlig N; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, 04103, Germany., Eberlein V; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, 04103, Germany., Conzelmann C; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Olari LR; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Rauch L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Lawrenz J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Weil T; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Müller JA; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Cardoso MB; Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo, 13083-970, Brazil., Gilg A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany., Larsson O; Adlego Biomedical AB, Solna, 171 65, Sweden., Höglund U; Adlego Biomedical AB, Solna, 171 65, Sweden., Pålsson SA; Department of Molecular Biosciences, The Wenner-Gren Institute Stockholm University, Stockholm, 10691, Sweden., Tvilum AS; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark., Løvschall KB; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark., Kristensen MM; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark., Spetz AL; Department of Molecular Biosciences, The Wenner-Gren Institute Stockholm University, Stockholm, 10691, Sweden., Hontonnou F; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78352, France., Galloux M; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78352, France., Grunwald T; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, 04103, Germany., Zelikin AN; Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Jul; Vol. 9 (20), pp. e2201378. Date of Electronic Publication: 2022 May 11.
DOI: 10.1002/advs.202201378
Abstrakt: Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core-shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
(© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje