| Autor: |
Silva PND; Grupo Oncoclínicas, Rio de Janeiro, RJ, Brazil., Valente PMS; Universidade Federal Fluminense-UFF, Programa de Pós-graduação em Ciências Aplicadas à Produtos para a Saúde-PPG CAPS, Niteroi, Rio de Janeiro, Brazil., Castilho SR; Universidade Federal Fluminense-UFF, Programa de Pós-graduação em Ciências Aplicadas à Produtos para a Saúde-PPG CAPS, Niteroi, Rio de Janeiro, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2023 Jul; Vol. 29 (5), pp. 1125-1134. Date of Electronic Publication: 2022 May 11. |
| DOI: |
10.1177/10781552221098426 |
| Abstrakt: |
Monoclonal antibodies, such as trastuzumab and rituximab, significantly contribute to the oncological therapeutic arsenal. However, they may be associated with the development of cardiotoxicity. This study collected data from clinical records of patients in the use of rituximab and trastuzumab in a private oncology clinic from 2017 to 2019. It also investigated cardiovascular adverse drug reactions and associated risk factors. Cardiotoxicity was defined as symptomatic in the presence of signs and symptoms suggestive of heart failure (HF) such as dyspnea, nocturnal cough, and fatigue, among others. Asymptomatic HF was confirmed by the decline in the left ventricular ejection fraction (LVEF) ≥10% of baseline or LVEF ≤50%. Among the 57 patients undergoing trastuzumab, 12 patients (21%) had cardiotoxicity and 8 patients (67%) had extreme or high-risk scores in the cardiotoxicity risk assessment algorithm. Among the 37 patients treated with rituximab, 3 patients (8%) had cardiotoxicity. The presence of previous diabetes mellitus significantly increased the risk of trastuzumab-induced cardiotoxicity ( p = 0.02). However, none of the other risk factors influenced the incidence of trastuzumab- and rituximab-induced cardiotoxicity, which the sample size may explain. More studies are needed to investigate the association of risk factors with cardiotoxicity induced by trastuzumab and rituximab, aiming to establish strategies to prevent and manage this effect early. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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