Soluble Receptor for Advanced Glycation End Products (sRAGE) Isoforms Predict Changes in Resting Energy Expenditure in Adults with Obesity during Weight Loss.

Autor:	Popp CJ; Center for Healthful Behavior Change, Department of Population Health, New York University Langone Health, New York, NY, USA., Zhou B; Division of Biostatistics, Department of Population Health, New York University Langone Health, New York, NY, USA., Manigrasso MB; Diabetes Research Program, Department of Medicine, New York University Langone Health, New York, NY, USA., Li H; Division of Biostatistics, Department of Population Health, New York University Langone Health, New York, NY, USA., Curran M; Center for Healthful Behavior Change, Department of Population Health, New York University Langone Health, New York, NY, USA., Hu L; Center for Healthful Behavior Change, Department of Population Health, New York University Langone Health, New York, NY, USA., St-Jules DE; Department of Nutrition, University of Nevada, Reno, Reno, NV, USA., Alemán JO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, USA., Vanegas SM; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, USA., Jay M; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, USA., Bergman M; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, USA., Segal E; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Sevick MA; Center for Healthful Behavior Change, Department of Population Health, New York University Langone Health, New York, NY, USA., Schmidt AM; Diabetes Research Program, Department of Medicine, New York University Langone Health, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Current developments in nutrition [Curr Dev Nutr] 2022 Mar 29; Vol. 6 (5), pp. nzac046. Date of Electronic Publication: 2022 Mar 29 (Print Publication: 2022).
DOI:	10.1093/cdn/nzac046
Abstrakt:	Background: Accruing evidence indicates that accumulation of advanced glycation end products (AGEs) and activation of the receptor for AGEs (RAGE) play a significant role in obesity and type 2 diabetes. The concentrations of circulating RAGE isoforms, such as soluble RAGE (sRAGE), cleaved RAGE (cRAGE), and endogenous secretory RAGE (esRAGE), collectively sRAGE isoforms, may be implicit in weight loss and energy compensation resulting from caloric restriction. Objectives: We aimed to evaluate whether baseline concentrations of sRAGE isoforms predicted changes (∆) in body composition [fat mass (FM), fat-free mass (FFM)], resting energy expenditure (REE), and adaptive thermogenesis (AT) during weight loss. Methods: Data were collected during a behavioral weight loss intervention in adults with obesity. At baseline and 3 mo, participants were assessed for body composition (bioelectrical impedance analysis) and REE (indirect calorimetry), and plasma was assayed for concentrations of sRAGE isoforms (sRAGE, esRAGE, cRAGE). AT was calculated using various mathematical models that included measured and predicted REE. A linear regression model that adjusted for age, sex, glycated hemoglobin (HbA1c), and randomization arm was used to test the associations between sRAGE isoforms and metabolic outcomes. Results: Participants ( n  = 41; 70% female; mean ± SD age: 57 ± 11 y; BMI: 38.7 ± 3.4 kg/m 2 ) experienced modest and variable weight loss over 3 mo. Although baseline sRAGE isoforms did not predict changes in ∆FM or ∆FFM, all baseline sRAGE isoforms were positively associated with ∆REE at 3 mo. Baseline esRAGE was positively associated with AT in some, but not all, AT models. The association between sRAGE isoforms and energy expenditure was independent of HbA1c, suggesting that the relation was unrelated to glycemia. Conclusions: This study demonstrates a novel link between RAGE and energy expenditure in human participants undergoing weight loss.This trial was registered at clinicaltrials.gov as NCT03336411. (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.)
Databáze:	MEDLINE
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