Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties.

Autor:	Vlaisavljević S; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Trg Dositeja Obradovića 3 21000 Novi Sad Serbia sanja.vlaisavljevic@dh.uns.ac.rs +381 21454065 +381 214852770., Jelača S; Department of Immunology, Institute for Biological Research 'Siniša Stanković', University of Belgrade Serbia., Zengin G; Department of Biology, Science Faculty, Selcuk University Konya Turkey., Mimica-Dukić N; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Trg Dositeja Obradovića 3 21000 Novi Sad Serbia sanja.vlaisavljevic@dh.uns.ac.rs +381 21454065 +381 214852770., Berežni S; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Trg Dositeja Obradovića 3 21000 Novi Sad Serbia sanja.vlaisavljevic@dh.uns.ac.rs +381 21454065 +381 214852770., Miljić M; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad Trg Dositeja Obradovića 3 21000 Novi Sad Serbia sanja.vlaisavljevic@dh.uns.ac.rs +381 21454065 +381 214852770., Stevanović ZD; Faculty of Agriculture, University of Belgrade Serbia.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2019 Nov 18; Vol. 9 (64), pp. 37474-37483. Date of Electronic Publication: 2019 Nov 18 (Print Publication: 2019).
DOI:	10.1039/c9ra08231j
Abstrakt:	The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications. Competing Interests: The authors declare there is no conflict of interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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