Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift.

Autor:	Zaitseva SO; Institute of Bioorganic Chemistry, Russian Academy of Sciences Miklukho-Maklaya 16/10 117997 Moscow Russia baranovmikes@gmail.com., Farkhutdinova DA; Department of Chemistry, Lomonosov Moscow State University Leninskie Gory 1/3 119991 Moscow Russia bochenkova@phys.chem.msu.ru., Baleeva NS; Institute of Bioorganic Chemistry, Russian Academy of Sciences Miklukho-Maklaya 16/10 117997 Moscow Russia baranovmikes@gmail.com., Smirnov AY; Institute of Bioorganic Chemistry, Russian Academy of Sciences Miklukho-Maklaya 16/10 117997 Moscow Russia baranovmikes@gmail.com., Zagudaylova MB; Institute of Bioorganic Chemistry, Russian Academy of Sciences Miklukho-Maklaya 16/10 117997 Moscow Russia baranovmikes@gmail.com., Shakhov AM; Semenov Institute of Chemical Physics of RAS Moscow Russia., Astafiev AA; Semenov Institute of Chemical Physics of RAS Moscow Russia.; Department of Chemistry, Lomonosov Moscow State University Leninskie Gory 1/3 119991 Moscow Russia bochenkova@phys.chem.msu.ru., Baranov MS; Institute of Bioorganic Chemistry, Russian Academy of Sciences Miklukho-Maklaya 16/10 117997 Moscow Russia baranovmikes@gmail.com.; Pirogov Russian National Research Medical University Ostrovitianov 1 Moscow 117997 Russia., Bochenkova AV; Department of Chemistry, Lomonosov Moscow State University Leninskie Gory 1/3 119991 Moscow Russia bochenkova@phys.chem.msu.ru.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2019 Nov 26; Vol. 9 (66), pp. 38730-38734. Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
DOI:	10.1039/c9ra08808c
Abstrakt:	We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo -bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl substituents makes them environmentally sensitive. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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