A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2- a ][1,3,5]triazines.
| Autor: | Lim FPL; School of Pharmacy, Monash University Malaysia Jalan Lagoon Selatan, Bandar Sunway Selangor Darul Ehsan 47500 Malaysia dolzhenkoav@gmail.com anton.dolzhenko@monash.edu +60-3-5514-6364 +60-3-5514-5867., Tan LY; School of Pharmacy, Monash University Malaysia Jalan Lagoon Selatan, Bandar Sunway Selangor Darul Ehsan 47500 Malaysia dolzhenkoav@gmail.com anton.dolzhenko@monash.edu +60-3-5514-6364 +60-3-5514-5867., Tiekink ERT; Research Centre for Crystalline Materials, School of Science and Technology, Sunway University Bandar Sunway Selangor Darul Ehsan 47500 Malaysia., Dolzhenko AV; School of Pharmacy, Monash University Malaysia Jalan Lagoon Selatan, Bandar Sunway Selangor Darul Ehsan 47500 Malaysia dolzhenkoav@gmail.com anton.dolzhenko@monash.edu +60-3-5514-6364 +60-3-5514-5867.; School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University GPO Box U1987 Perth Western Australia 6845 Australia. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2018 Jun 12; Vol. 8 (38), pp. 21495-21504. Date of Electronic Publication: 2018 Jun 12 (Print Publication: 2018). |
| DOI: | 10.1039/c8ra03703e |
| Abstrakt: | A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2- a ][1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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