Complexes of ortho-Phthalic Acid in Spontaneous Animal Tumors.

Autor: Lozovskaya EA; Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russia. molodegny31@mail.ru., Nikiforov SB; Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russia., Enikeev AG; Siberian Institute of Plants Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia., Kostyunin KY; Irkutsk State Medical University, Irkutsk, Russia., Sudakov NP; Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russia.; Limnological Institute, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia., Semenov AA; Siberian Institute of Plants Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Apr; Vol. 503 (1), pp. 112-114. Date of Electronic Publication: 2022 May 10.
DOI: 10.1134/S1607672922010070
Abstrakt: The presence of diethyl-, dibutyl-, and 2-ethylhexyl phthalates in spontaneous animal tumors was determined for the first time. Small-cell breast cancer of the dog and Ehrlich ascites carcinoma with the cells are particularly rich of these compounds. It is assumed that the level of phthalates in these cells is due to the activity of expression of nuclear receptors for estrogens and progesterone, as well as the peculiarities of the metabolism of xenobiotics. The accumulation of these compounds in tumor cells can increase their malignancy. The data obtained can be used for development of new diagnostic and therapeutic technologies.
(© 2022. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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