Prenatal Stress and Adaptive Behavior of Offspring: The Role of Placental Serotonin.

Autor: Bondarenko NS; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia., Voronova SN; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia., Voronezhskaya EE; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia., Melnikova VI; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. v.melnikova@idbras.ru.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Apr; Vol. 503 (1), pp. 104-107. Date of Electronic Publication: 2022 May 10.
DOI: 10.1134/S160767292202003X
Abstrakt: The effect of mild prenatal stress in mice, leading to an increase in the placental serotonin level, on the formation of adaptive behavior in male offspring at the age of 35 days was studied. It was shown that, in BalbC mice, daily immobilization for 1 h during the period from 11 to 14 days of pregnancy led to an increase in placental and fetal serotonin levels on the 15th day of prenatal development. According to "resident-intruder" behavioral test, the prenatally stressed mice showed more reactive behavior in adulthood and low tendency to defend their territory. Thus, placental serotonin, formed under the stress condition, may act as a mediator between the environment and the fetuses and determine the adaptive behavior of offspring.
(© 2022. The Author(s).)
Databáze: MEDLINE
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