Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs.

Autor:	Stattin EL; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden eva-lena.stattin@igp.uu.se., Hagström E; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Dahl N; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Strömsöe A; School of Education, Health and Social Studies, Dalarna University, Falun, Sweden.; Centre for Clinical Research Dalarna, Uppsala University, Falun, Sweden., Delgado-Vega AM; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Klar J; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Svennblad B; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Börjesson M; Department of Molecular and Clinial Medicine, Sahlgrenska Academy, Göteborg university, Göteborg, Sweden.; Center for Health and Performance, Department of Food, Nutrition and Sport Science, Göteborg university, Göteborg, Sweden., Wisten A; Department of Community Medicine and Rehabilitation, Geriatric Medicine, Sunderby Research Unit, Umeå university, Umeå, Sweden.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 May 10; Vol. 12 (5), pp. e055557. Date of Electronic Publication: 2022 May 10.
DOI:	10.1136/bmjopen-2021-055557
Abstrakt:	Purpose: The rationale behind the SUDden cardiac Death in the Young (SUDDY) cohort was to provide a complete nationwide, high-quality platform with integrated multisource data, for clinical and genetic research on sudden cardiac death (SCD) in the young, with the ultimate goal to predict and prevent SCD. Participants: The cohort contains all SCD victims <36 years, in Sweden during the period 2000-2010. We assigned five population-based controls per case, together with parents of cases and controls, in total 15 633 individuals. Data of all individuals were extracted from multiple mandatory registries; the National Patient Registry, the Medical Birth Registry, the Prescribed Drug registry, the Cause of Death registry, the Multigeneration Registry, combined with socioeconomic data from Statistics Sweden. From SCD victims, the autopsy report, medical records, ECGs, parental information and biological samples were gathered. Findings to Date: We identified 903 individuals diagnosed with SCD (67% men, 33% women). The cases comprised 236 infants <1 year of age (26%), 90 individuals aged 1-15 years (10%), 186 individuals aged 15-25 years (21%) and 391 aged 25-35 years (43%). Hospitalisations and outpatient clinic visits due to syncope were significantly more common among cases than controls. DNA obtained from dried blood spots tests (DBS) stored from birth was equally suitable as venous blood samples for high-throughput genetic analysis of SCD cases. Future Plans: We will explore the SUDDY cohort for symptoms and healthcare consumption, socioeconomic variables and family history of SCD. Furthermore, we will perform whole exome sequencing analysis on DNA of cases obtained from DBS or postmortem samples together with parental blood samples in search for gene variants associated with cardiac disease. The genetic analysis together with data compiled in the nationwide cohort is expected to improve current knowledge on the incidence, aetiology, clinical characteristics and family history of SCD. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu