COVID-19 associated cognitive impairment: A systematic review.

Autor: Tavares-Júnior JWL; Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: wagnerleoneljr@gmail.com., de Souza ACC; Hospital Universitário Walter Cantídio (HUWC), Fortaleza-CE, Brazil. Electronic address: anaceliacs.doc@gmail.com., Borges JWP; Department of Nursing, Universidade Federal do Piauí, Teresina, PI, Brazil. Electronic address: josewictoborges@gmail.com., Oliveira DN; Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: danilonunesoliveira@gmail.com., Siqueira-Neto JI; Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: jibiapinaneto@yahoo.com.br., Sobreira-Neto MA; Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: manoelsobreira@yahoo.com.br., Braga-Neto P; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, CE, Brazil. Electronic address: pbraganeto@ufc.br.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2022 Jul; Vol. 152, pp. 77-97. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1016/j.cortex.2022.04.006
Abstrakt: Introduction: COVID-19 has a wide range of clinical manifestations. Neurological manifestations in COVID-19 patients were demonstrated during the pandemic, including cognitive impairment. This study aimed to determine any relationship between COVID-19 and cognitive complaints, such as dementia, mild cognitive impairment (MCI), or subjective cognitive decline (SCD).
Methods: We performed a systematic review of MEDLINE via Ebsco, Cochrane EMBASE, SCOPUS, and LILACS electronic databases of observational studies with COVID-19 patients confirmed by serology or PCR who developed new cognitive impairment or deteriorated from previous cognitive impairment after infection. This review protocol was recorded on PROSPERO with registration number CRD 42021241590.
Results: A total of 3.520 articles were retrieved and read. Twenty-two studies were selected for our review. A wide range of cognitive assessment tools (n = 25) was used. The most described affected domains in these studies were executive functions, attention, and episodic memory. Thirteen studies showed a pattern of cognitive impairment in processing speed, inattention, or executive dysfunction assessed through working memory.
Conclusion: This review highlights the high frequency of cognitive impairment after COVID-19 infection. However, we were unable to differentiate whether the cognitive impairment found corresponded to mild cognitive impairment or dementia through data from selected studies, and this issue serves as one objective of future studies to be addressed on this topic.
Competing Interests: Declaration of competing interest One of the authors (Pedro Braga Neto) received funding from the Brazilian National Council for Scientific and Technological Development (CNPq) as research grant funding and from the Brazilian Funding Grant Number 88881.505364/2020-01 from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). José Wagner Leonel Tavares Júnior, Ana Célia Caetano de Souza, José Wicto Pereira Borges, Danilo Nunes Oliveira, José Ibiapina Siqueira Neto, Manoel Alves Sobreira Neto declare that they have no conflict of interest.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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