Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.

Autor:	Paiva I; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Cellai L; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Meriaux C; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Poncelet L; ImaBiotech SAS, Parc Eurasanté, Loos, France., Nebie O; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Saliou JM; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UAR CNRS 2014 - US Inserm 41 - PLBS, Lille, France., Lacoste AS; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UAR CNRS 2014 - US Inserm 41 - PLBS, Lille, France., Papegaey A; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Drobecq H; Centre d'Infection et d'Immunité de Lille (CIIL) - INSERM U1019 - UMR 9017, Lille, France., Le Gras S; University of Strasbourg, CNRS UMR7104, Inserm U1258 - GenomEast Platform - Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France., Schneider M; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany., Malik EM; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany., Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany., Faivre E; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Carvalho K; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Gomez-Murcia V; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Vieau D; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Thiroux B; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Eddarkaoui S; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Lebouvier T; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France.; CHU Lille, Memory Clinic, Lille, France., Schueller E; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Tzeplaeff L; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Grgurina I; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Seguin J; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Stauber J; ImaBiotech SAS, Parc Eurasanté, Loos, France., Lopes LV; Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisbon, Portugal., Buée L; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Buée-Scherrer V; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Cunha RA; Center for Neuroscience and Cell Biology (CNC) and.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Ait-Belkacem R; ImaBiotech SAS, Parc Eurasanté, Loos, France., Sergeant N; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France., Annicotte JS; University of Lille, INSERM, CNRS, CHU Lille, Institut Pasteur de Lille, Inserm U1283/CNRS UMR8199 - EGID, Lille, France.; University of Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Boutillier AL; University of Strasbourg, CNRS, UMR7364 - Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Blum D; University of Lille, Inserm, CHU Lille, UMR-S1172 Lille Neuroscience & Cognition (LilNCog), Lille, France.; Alzheimer and Tauopathies, LabEx DISTALZ, France.
Jazyk:	angličtina
Zdroj:	The Journal of clinical investigation [J Clin Invest] 2022 Jun 15; Vol. 132 (12).
DOI:	10.1172/JCI149371
Abstrakt:	Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus at the epigenomic, proteomic, and metabolomic levels. Caffeine lowered metabolism-related processes (e.g., at the level of metabolomics and gene expression) in bulk tissue, while it induced neuron-specific epigenetic changes at synaptic transmission/plasticity-related genes and increased experience-driven transcriptional activity. Altogether, these findings suggest that regular caffeine intake improves the signal-to-noise ratio during information encoding, in part through fine-tuning of metabolic genes, while boosting the salience of information processing during learning in neuronal circuits.
Databáze:	MEDLINE
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