In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis.
| Autor: | Ajucarmelprecilla A; Medical Microbiology Unit, Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu, India., Pandi J; Medical Microbiology Unit, Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu, India.; Chimertech Private Limited, Chennai, India., Dhandapani R; Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India., Ramanathan S; Medical Microbiology Unit, Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu, India., Chinnappan J; Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India., Paramasivam R; Chimertech Private Limited, Chennai, India., Thangavelu S; Medical Microbiology Unit, Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu, India., Mohammed Ghilan AK; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia., Aljohani SAS; Department of Basic Medical Sciences, Faculty of Medicine, Alrayan Colleges, Almadinah Almunawarah, Saudi Arabia., Oyouni AAA; Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia., Farasani A; Biomedical Research Unit, Medical Research Center, Jazan University, Jazan 45142, Saudi Arabia.; Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia., Altayar MA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Althagafi HAE; Biology Department, Faculty of Science and Arts, Al-Mikhwah, Al-Baha University, Saudi Arabia., Alzahrani OR; Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia., Durairaj K; Zoonosis Research Center, School of Medicine, Wonkwang University, Iksan, Republic of Korea., Shrestha A; Research Institute of Agriculture and Applied Science, Tokha Kathmandu 2356, Nepal.; Department of Plant Protection, Himalayan College of Agricultural Sciences and Technology, Kalanki, 44600 Kathmandu, Nepal. |
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| Jazyk: | angličtina |
| Zdroj: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2022 Apr 30; Vol. 2022, pp. 6316158. Date of Electronic Publication: 2022 Apr 30 (Print Publication: 2022). |
| DOI: | 10.1155/2022/6316158 |
| Abstrakt: | Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533 and GSE54129). The genes were confirmed to be part of the PPI network for gastric cancer pathogenesis and prognosis. In Cytoscape, the CytoHubba module was used to discover the hub genes. Responsible hub genes were identified. Data from Kaplan-Meier plotter confirmed the predictive value of these distinct genes in various stages of gastric malignancy. Upregulated and downregulated genes were identified to utilize for further analysis. Positive regulation by a host of viral process, positive regulation of granulocyte differentiation, negative regulation of histone H Competing Interests: All authors declare that they have no conflicts of interest. (Copyright © 2022 Arulprakasam Ajucarmelprecilla et al.) |
| Databáze: | MEDLINE |
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