Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B 12 status among young Laotian children: a randomized controlled trial.

Autor: Hinnouho GM; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA. gmhinnouho@hki.org.; Helen Keller International, Washington, DC, USA. gmhinnouho@hki.org., Hampel D; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.; USDA, ARS Western Human Nutrition Research Center, Davis, CA, USA., Shahab-Ferdows S; USDA, ARS Western Human Nutrition Research Center, Davis, CA, USA., Barffour MA; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.; University of Missouri School of Medicine, Columbia, MO, USA.; Public Health Program, College of Health and Human Services, Missouri State University, Springfield, MO, USA., McAnena L; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Arnold CD; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA., Ryan Wessells K; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA., Kounnavong S; Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic., Allen LH; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.; USDA, ARS Western Human Nutrition Research Center, Davis, CA, USA., McNulty H; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Hess SY; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2022 Oct; Vol. 61 (7), pp. 3423-3435. Date of Electronic Publication: 2022 May 09.
DOI: 10.1007/s00394-022-02890-3
Abstrakt: Purpose: To assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B 12 status among young Laotian children.
Methods: Children (n = 1704) aged 6-23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B 12 along with 11 other micronutrients) or placebo and followed for ~ 36 weeks. In a randomly selected sub-sample of 260 children, erythrocyte thiamine diphosphate (eThDP), plasma folate and B 12 concentrations, and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin biomarker) were assessed at baseline and endline.
Results: There was no treatment effect on endline eThDP concentrations (110.6 ± 8.9 nmol/L in MNP vs. 109.4 ± 8.9 nmol/L in placebo group; p = 0.924), EGRac (1.46 ± 0.3 vs. 1.49 ± 0.3; p = 0.184) and B 12 concentrations (523.3 ± 24.6 pmol/L vs. 515.9 ± 24.8 pmol/L; p = 0.678). Likewise, the prevalence of thiamine, riboflavin, and B 12 deficiencies did not differ significantly between the two groups. However, endline folate concentration was significantly higher in the MNP compared to the placebo group (28.2 ± 0.8 nmol/L vs 19.9 ± 0.8 nmol/L, respectively; p < 0.001), and correspondingly, the prevalence of folate deficiency was significantly lower in the MNP group (1.6% vs 17.4%; p = 0.015).
Conclusions: Compared to a placebo, daily MNP for 9 months increased only folate but not thiamine, riboflavin, or B 12 status in young Laotian children.
Trial Registration: The trial was registered at www.
Clinicaltrials: gov (NCT02428647) on April 29 2015.
(© 2022. The Author(s).)
Databáze: MEDLINE
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