Uric acid is associated with morpho-functional adipose tissue markers in apparently healthy subjects.

Autor: Reyes-Barrera J; Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Medina-Urrutia AX; Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Jorge-Galarza E; Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Osorio-Alonso H; Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Arellano-Buendía AS; Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Olvera-Mayorga G; Departments of Nutrition and Health Research Center, Instituto Nacional de Salud Pública, Cuernavaca City, Mexico., Sánchez-Ortiz NA; Departments of Nutrition and Health Research Center, Instituto Nacional de Salud Pública, Cuernavaca City, Mexico., Torres-Tamayo M; Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Tovar Palacio AR; Department of Nutrition Physiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Torre-Villalvazo I; Department of Nutrition Physiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Electronic address: ivan.torrev@incmnsz.mx., Juárez-Rojas JG; Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: gaboyk2@gmail.com.
Jazyk: angličtina
Zdroj: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2022 Jun 01; Vol. 531, pp. 368-374. Date of Electronic Publication: 2022 May 06.
DOI: 10.1016/j.cca.2022.05.002
Abstrakt: Background: Studies have focused on the search of novel biomarkers that allow to easily identify dysfunctional adipose tissue (AT). Uric acid (UA) could be produced and reabsorbed by AT. It has been suggested that the increases of UA concentrations participates in AT dysfunction. We investigated the association of UA with morpho-functional adipose tissue markers in apparently healthy subjects.
Methods: Forty apparently healthy individuals were included. Dietary habits and anthropometrical features were evaluated. Circulating concentrations of UA, adiponectin, leptin, and plasminogen activator inhibitor-1 (PAI-1) were quantified. Periumbilical subcutaneous AT samples were obtained and adipocyte number, adipocyte area, and macrophages content were assessed.
Results: The present study included 40 healthy subjects (67% women) with an average age of 57 ± 9 y, BMI of 26 ± 4 (kg/m 2 ). UA showed a significant association with the number and mean area of adipocytes, macrophages number, adiponectin, and PAI-1. Although UA was independently associated with the number and mean area of adipocytes, macrophages number, adiponectin into the adjusted multivariable model.
Conclusion: UA concentrations are associated with morpho-functional adipose tissue markers. Our results underscore the importance of UA as one earlier instigator of adipose tissue dysfunction in subjects without metabolic abnormalities.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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