| Autor: |
Khac Hung N; Center For High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Quang DN; Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam., Quang LD; Institute for Tropical Technology (VAST), Hanoi, Vietnam., Minh TT; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Dung TN; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Duong PQ; Center For High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Tung NH; Faculty of Pharmacy, PHENIKAA University, Hanoi, Vietnam., Hoang VD; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam. |
| Abstrakt: |
Phytochemical study on the methanolic extract of the leaves of Vietnamese plant Gardenia philastrei Pierre ex Pit. has led to the isolation of a new cycloartane coronalyl acetate ( 1 ) together with six known ones, coronlolide methyl ester ( 2 ), sootepin D ( 3 ), coronalolide ( 4 ), coronalolic acid ( 5 ), sootepin G ( 6 ) and 23-deoxojessic acid ( 7 ). Their structures were elucidated by a combination of 2 D NMR and HR-ESI-MS spectroscopies. These compounds ( 1-7 ) were tested for their anti-inflammatory activity. The result showed that six compounds ( 1 - 6 ) inhibit LPS-induced nitric oxide production in RAW264.7 macrophages with their IC 50 values ranging from 3.76 - 75.47 µg/mL. This is the first report on the chemical constituents and anti-inflammatory activity of the G. philastrei . |
