Invasive Pulmonary Cryptococcal Infection Masquerading as Lung Cancer with Brain Metastases: A Case Report.

Autor:	Echieh C; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Nwagboso C; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Ogbudu S; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Eze J; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Ochang E; Department of Microbiology, University of Calabar, Calabar, Cross River State, Nigeria., Jibrin P; Department of Pathology, National Hospital, Abuja, Nigeria., Etiuma A; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria., Bassey O; Division of Cardiothoracic and Vascular Surgery, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of the West African College of Surgeons [J West Afr Coll Surg] 2020 Jan-Mar; Vol. 10 (1), pp. 30-34. Date of Electronic Publication: 2022 Mar 05.
DOI:	10.4103/jwas.jwas_47_21
Abstrakt:	Cryptococcosis, a global disease problem, seen frequently in the immuno-suppressed, also affects patients without apparent immuno-suppression. Pulmonary cryptococcosis patients often present as cryptococcal pneumonia, whereas intracranial cryptococcosis presents with meningitis. We present a 33-year-old immunocompetent man, diagnosed with invasive pulmonary cryptococcal disease with spread to the brain. This case is unique because the patient was previously treated for tuberculosis and presented with typical bronchopulmonary thoracic, extra-thoracic as well as computed tomography (CT) scan features suggestive of lung cancer. Cryptococcosis was diagnosed by identification of oval thick-walled yeast on histology of lung biopsy specimen. The patient was treated with flucytosine and fluconazole initially and subsequently with Amphotericin B and fluconazole. He made clinical improvement with the resolution of symptoms but had residual radiological features. Invasive cryptococcosis affecting the lung and brain may present with a clinical picture similar to metastatic lung cancer. We recommend routine fungal stains and fungal culture in suspected cases. Competing Interests: There are no conflicts of interest. (Copyright: © 2022 Journal of West African College of Surgeons.)
Databáze:	MEDLINE
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