Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry.

Autor: Alzubaidi AN; Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA., Sekoulopoulos S; Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA., Pham J; Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA., Walter V; Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA., Fuletra JG; Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA., Raman JD; Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Jazyk: angličtina
Zdroj: Journal of kidney cancer and VHL [J Kidney Cancer VHL] 2022 Apr 18; Vol. 9 (2), pp. 7-12. Date of Electronic Publication: 2022 Apr 18 (Print Publication: 2022).
DOI: 10.15586/jkcvhl.v9i2.219
Abstrakt: Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients.
Competing Interests: The authors declare no potential conflict of interest
(Copyright: Alzubaidi A.N, et al.)
Databáze: MEDLINE
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