A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.

Autor: Sader M; Translational Neuroscience, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Williams JHG; Translational Neuroscience, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Waiter GD; Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Jazyk: angličtina
Zdroj: European eating disorders review : the journal of the Eating Disorders Association [Eur Eat Disord Rev] 2022 Sep; Vol. 30 (5), pp. 560-579. Date of Electronic Publication: 2022 May 07.
DOI: 10.1002/erv.2915
Abstrakt: Recent research reports Anorexia Nervosa (AN) to be highly dependent upon neurobiological function. Some behaviours, particularly concerning food selectivity are found in populations with both Autism Spectrum Disorder (ASD) and AN, and there is a proportionally elevated number of anorexic patients exhibiting symptoms of ASD. We performed a systematic review of structural MRI literature with the aim of identifying common structural neural correlates common to both AN and ASD. Across 46 ASD publications, a meta-analysis of volumetric differences between ASD and healthy controls revealed no consistently affected brain regions. Meta-analysis of 23 AN publications revealed increased volume within the orbitofrontal cortex and medial temporal lobe, and adult-only AN literature revealed differences within the genu of the anterior cingulate cortex. The changes are consistent with alterations in flexible reward-related learning and episodic memory reported in neuropsychological studies. There was no structural overlap between ASD and AN. Findings suggest no consistent neuroanatomical abnormality associated with ASD, and evidence is lacking to suggest that reported behavioural similarities between those with AN and ASD are due to neuroanatomical structural similarities.
(© 2022 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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