WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour.

Autor: Chen SL; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Liu BT; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Lee WP; Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Liao SB; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Deng YB; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Wu CL; Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan.; Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan., Ho SM; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Shen BX; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Khoo GH; Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan., Shiu WC; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Chang CH; Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan.; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan.; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan., Shih HW; Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan., Wen JK; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan., Lan TH; Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan.; Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Lin CC; Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai YC; Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan. yctsaibio@thu.edu.tw., Tzeng HF; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan. hftzeng@ncnu.edu.tw., Fu TF; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan. tffu@ncnu.edu.tw.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 May 06; Vol. 13 (1), pp. 2518. Date of Electronic Publication: 2022 May 06.
DOI: 10.1038/s41467-022-30165-2
Abstrakt: The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABA A receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.
(© 2022. The Author(s).)
Databáze: MEDLINE
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