Fibroepithelial lesions of the breast: A review of recurring diagnostic issues.

Autor:	Seow DYB; Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore. Electronic address: dominiqueseow@gmail.com., Tay TKY; Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore., Tan PH; Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore. Electronic address: tan.puay.hoon@singhealth.com.sg.
Jazyk:	angličtina
Zdroj:	Seminars in diagnostic pathology [Semin Diagn Pathol] 2022 Sep; Vol. 39 (5), pp. 333-343. Date of Electronic Publication: 2022 Apr 19.
DOI:	10.1053/j.semdp.2022.04.001
Abstrakt:	Breast fibroepithelial lesions, which are composed of biphasic epithelial and stromal proliferations, comprise the fascinating spectrum of fibroadenomas and phyllodes tumours. Common difficulties surrounding their diagnosis include distinguishing between cellular fibroadenomas and benign phyllodes tumours, grading phyllodes tumours, classifying fibroepithelial lesions in paediatric patients, and handling surgical margins. Recent molecular advances have provided insights into the pathogenesis of fibroepithelial lesions and may offer diagnostic, prognostic, and therapeutic information. In this review, we briefly revisit the pathological features of fibroadenomas and phyllodes tumours, discuss common diagnostic dilemmas and management implications, and examine their key molecular characteristics. (Copyright © 2022. Published by Elsevier Inc.)
Databáze:	MEDLINE
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