A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor.

Autor: De Franco YP; Instituto de Prevision Social (IPS) Hospital. Asuncion, Paraguay., Segovia N; Department of Laboratory Medicine. Instituto de Prevision Social (IPS) Hospital. Asuncion, Paraguay., Marx YF; Department of Obstetrics and Gynecology. William Beaumont Hospital. Royal Oak, MI, USA., Hoxhaj R; Internal Medicine Department. WellStar Health System. Kennestone Regional Hospital. Marietta GA, USA., Palacios CF; Nephrology, Pulmonary and Critical Care Medicine Department. WellStar Health System. Marietta GA, USA.
Jazyk: angličtina
Zdroj: Romanian journal of internal medicine = Revue roumaine de medecine interne [Rom J Intern Med] 2022 Sep 22; Vol. 60 (3), pp. 160-165. Date of Electronic Publication: 2022 Sep 22 (Print Publication: 2022).
DOI: 10.2478/rjim-2022-0007
Abstrakt: Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study. Methods: Urine podocalyxin levels were measured in 115 pregnant women. Of these, 12 women were in the second trimester of gestation, 57 in the third trimester and 46 women were in labor. Results: The median [IQR] urinary podocalyxin levels were 0.81 [0.27, 3.68], 0.92 [0.44, 5.49] and 64.7 [30.5, 106.3] ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (p<0.0001). Patients with hematuria during labor had higher levels of urinary podocalyxin (128.6 [79.8, 169.6] ng/mg creatinine. There was a moderate correlation between gestational age and urinary podocalyxin levels (r=0.63, p<0.0001). Conclusion: Urinary podocalyxin levels were low in normal pregnancies and increased significantly during labor and with hematuria.
(© 2022 Ylbe Palacios De Franco et al., published by Sciendo.)
Databáze: MEDLINE
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