Thyroid autoimmunity in Greenlandic Inuit.

Autor:	Noahsen P; Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Ilisimatusarfik, University of Greenland, Nuuk, Greenland.; National Board of Health, Nuuk, Greenland., Rex KF; Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Ilisimatusarfik, University of Greenland, Nuuk, Greenland.; Department of Internal Medicine, Queen Ingrid's Hospital, Nuuk, Greenland., Bülow Pedersen I; Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Mulvad G; Ilisimatusarfik, University of Greenland, Nuuk, Greenland.; Queen Ingrid's Health Care Centre, Nuuk, Greenland., Florian-Sørensen HC; Tasiilaq Health Care Center, Tasiilaq, Greenland., Pedersen ML; Steno Diabetes Center Nuuk, Nuuk, Greenland., Andersen S; Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Ilisimatusarfik, University of Greenland, Nuuk, Greenland.; Department of Internal Medicine, Queen Ingrid's Hospital, Nuuk, Greenland.; Department of Geriatric Medicine, Aalborg University Hospital, Aalborg, Denmark.
Jazyk:	angličtina
Zdroj:	European thyroid journal [Eur Thyroid J] 2022 May 27; Vol. 11 (3). Date of Electronic Publication: 2022 May 27.
DOI:	10.1530/ETJ-22-0071
Abstrakt:	Objective: This study aimed to provide the first data on the occurrence of thyroid autoimmunity among Inuit in Greenland, a distinct ethnic group who is not iodine deficient. Design: This study is a population-based cross-sectional study. Methods: Data were collected in Nuuk in West Greenland and in Ammassalik district in East Greenland. Information on lifestyle, diet and diseases was obtained using questionnaires. Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroid-stimulating hormone (TSH) were measured in serum. Iodine and creatinine were measured in spot urine samples. Results: The participation rate was 95% with 434 Inuit participants; 75% were smokers. Iodine excretion was 169 µg/24 h in urban West Greenland, 224 µg/24 h in the main town and 228 µg/24 h in settlements in rural East Greenland. TPOAb, TgAb or either of these was measured in the serum from 3.7, 5.9 and 8.3% of participants, respectively. TPOAb or TgAb was found in 9.3% of Inuit women and 7.5% of men and more frequently, in East Greenland Inuit with the higher iodine excretion (P = 0.02). There was some evidence suggesting that thyroid autoimmunity was more frequent among non-smokers (12.5%) compared to smokers (7.0%). Harbouring a thyroid autoantibody was most frequent in participants with TSH above 3.6 mIU/L (P < 0.001). Conclusion: Thyroid autoantibodies were rare among Greenland Inuit. While iodine nutrition was associated with autoimmunity similarly to other ethnic groups, the influence of sex and smoking was limited. This could suggest genetic component in Inuit, but the impact of cold, selenium and persistent organic pollutants needs to be elucidated.
Databáze:	MEDLINE
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