In vitro cytotoxicity and antibiotic application of green route surface modified ferromagnetic TiO 2 nanoparticles.

Autor: Atique Ullah AKM; Nanoscience and Technology Research Laboratory, Atomic Energy Centre, Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh atique.chem@gmail.com atique.chem@baec.gov.bd.; Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh., Tamanna AN; Department of Physics, University of Dhaka Dhaka 1000 Bangladesh., Hossain A; Department of Physical and Inorganic Chemistry, Institute of Natural Sciences and Mathematics, Ural Federal University 620000 Yekaterinburg Russia., Akter M; Graduate School of Environmental Science, Hokkaido University 060-0810 Sapporo Japan., Kabir MF; Department of Physics, University of Dhaka Dhaka 1000 Bangladesh., Tareq ARM; Environmental Organic Chemistry Laboratory, Chemistry Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh., Fazle Kibria AKM; Nuclear Safety, Security and Safeguards Division, Bangladesh Atomic Energy Commission Dhaka 1207 Bangladesh., Kurasaki M; Graduate School of Environmental Science, Hokkaido University 060-0810 Sapporo Japan., Rahman MM; Department of Physics, University of Dhaka Dhaka 1000 Bangladesh., Khan MNI; Materials Science Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2019 Apr 30; Vol. 9 (23), pp. 13254-13262. Date of Electronic Publication: 2019 Apr 30 (Print Publication: 2019).
DOI: 10.1039/c9ra01395d
Abstrakt: The enormous numbers of applications of TiO 2 nanoparticles (NPs) cause concern about their risk to the environment and human health. Consequently, motivated by the necessity of searching for new sources of TiO 2 NPs of low cytotoxicity with antibacterial activity, we synthesized TiO 2 NPs by a green route using a solution of titanium(iv) isopropoxide as a precursor and an aqueous extract of Artocarpus heterophyllus leaf as a reducing and surface modifying agent. We investigated their structure, shape, size, and magnetic properties, and evaluated their antibiotic application and cytotoxicity. The synthesized TiO 2 NPs were applied against two Gram-negative bacteria ( E. coli and S. typhimurium ) and two Gram-positive bacteria ( S. aureus and B. subtilis ) to observe their antibacterial activity; and eventually clear zones of inhibition formed by the TiO 2 NPs were obtained. Moreover, after exposing the synthesized TiO 2 NPs to HeLa cells (carcinoma cells) and Vero cells (normal cells), no toxic effect was found up to a dose of 1000 mg L -1 , indicating the safe use of the samples up to at least 1000 mg L -1 . However, toxic effects on HeLa cells and Vero cells were observed at doses of 2000 mg L -1 and 3000 mg L -1 , respectively. These results indicate the safe use of Artocarpus heterophyllus leaf extract mediated synthesized TiO 2 NPs in their potential applications.
Competing Interests: The authors declare no conflict of interest.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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