Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines.
| Autor: | Maujean T; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LabEX MEDALIS, Faculté de Pharmacie LIT UMR 7200 Strasbourg F-67000 France dominique.bonnet@unistra.fr gulea@unistra.fr., Girard N; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LabEX MEDALIS, Faculté de Pharmacie LIT UMR 7200 Strasbourg F-67000 France dominique.bonnet@unistra.fr gulea@unistra.fr., Ganesan A; School of Pharmacy, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK., Gulea M; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LabEX MEDALIS, Faculté de Pharmacie LIT UMR 7200 Strasbourg F-67000 France dominique.bonnet@unistra.fr gulea@unistra.fr., Bonnet D; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LabEX MEDALIS, Faculté de Pharmacie LIT UMR 7200 Strasbourg F-67000 France dominique.bonnet@unistra.fr gulea@unistra.fr. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2020 Dec 07; Vol. 10 (71), pp. 43358-43370. Date of Electronic Publication: 2020 Dec 07 (Print Publication: 2020). |
| DOI: | 10.1039/d0ra09457a |
| Abstrakt: | Nitrogen-containing heterocycles represent a major source of pharmacological probes and drug candidates. To extend their molecular diversity and their potential biological activities, it is of importance to design and synthesize new N-heterocyclic scaffolds. Therefore, aza-diketopiperazines (aza-DKPs), the aza analogues of well-known 2,5-diketopiperazines (DKPs), emerged as a promising new scaffold. Although the first synthesis of an aza-DKP dates from 1951, significant developments have been made during the last decade. This feature article summarizes the different synthetic strategies to access and functionalise aza-DKPs. Their biological properties and potential applications in medicinal chemistry and drug discovery are discussed as well. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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