[HemoTypeSC screening for sickle cell disease in the Democratic Republic of Congo (DRC): a case from the city of Kindu].

Autor:	Aimé AK; Département de Pédiatrie, Faculté de Médecine, Université de Kindu, Kindu, République Démocratique du Congo.; Unité de Prévention et Contrôle des Maladies, Faculté de Médecine, Université de Kindu, Kindu, République Démocratique du Congo.; Département de Pédiatrie, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, République Démocratique du Congo., Etienne SM; Département de Pédiatrie, Faculté de Médecine, Université de Kindu, Kindu, République Démocratique du Congo.; Unité de Prévention et Contrôle des Maladies, Faculté de Médecine, Université de Kindu, Kindu, République Démocratique du Congo., Mbongi D; Centre Hospitalier Mère-Enfant de Monkole, Kinshasa, République Démocratique du Congo., Nsonso D; Centre Hospitalier Mère-Enfant de Monkole, Kinshasa, République Démocratique du Congo., Serrao E; Silver Lake Research Corporation, Azusa, California, United States of America., Léon TMM; Centre Hospitalier Mère-Enfant de Monkole, Kinshasa, République Démocratique du Congo., Oscar LN; Département de Pédiatrie, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, République Démocratique du Congo., Stanis WO; Département de Pédiatrie, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, République Démocratique du Congo.
Jazyk:	francouzština
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2022 Feb 16; Vol. 41, pp. 134. Date of Electronic Publication: 2022 Feb 16 (Print Publication: 2022).
DOI:	10.11604/pamj.2022.41.134.30187
Abstrakt:	Early detection of sickle cell disease is crucial to improve people's survival. Both financial and geographic accessibility to sickle cell disease tools are barriers to universal screening in developing countries. The purpose of this study was to determine the hospital prevalence of sickle cell disease and to assess the reliability of a rapid diagnostic tool, HemoTypeSC, in a resource-limited environment. We conducted a prospective cross-sectional descriptive study in the Department of Pediatrics of 5 health facilities in the city of Kindu, Maniema province, DRC, over a period of 10 months. The study consisted of HemoType SC rapid test screening for sickle cell disease and then diagnostic confirmation by hemoglobin electrophoresis. A total of 448 children less than 5 years of age were enrolled in the study. The overall hospital prevalence of patients with sickle cell disease was 31.9%, of whom 12.7% were homozygous (SS) and 19.2% trait carriers; the level of suspicion for sickle cell disease in hospitals was 6%; the clinical presumption regarding sickle cell disease was 8%; HemoType SC rapid test had good indicators of validity for the detection of hemoglobins A and S. The study shows that the hospital prevalence of major sickle cell disease is higher in children under 5 years of age with respect to clinical suspicion in the absence of laboratory tests. HemoTypeSC rapid test seems to be a reliable tool for the screening of the disease in the city of Kindu, a resource-limited environment. Competing Interests: Les auteurs ne déclarent aucun conflit d´interêts. (Copyright: Abdala Kingwengwe Aimé et al.)
Databáze:	MEDLINE
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