Glioblastoma Multiforme With CDKN2A, Loss of PTEN and EGFR Amplification, and Diffuse Distant Organ Metastasis Treated With Six Lines of Therapy: A Case Report and Literature Review.
| Autor: | Aslan F; Department of Medical Oncology, Yüksek İhtisas University Medical Park Ankara Hospital, Ankara, TUR., Günaydın E; Department of Radiology, Yüksek İhtisas University Medical Park Ankara Hospital, Ankara, TUR., Yukruk F; Department of Pathology, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, TUR., Güvenç İ; Department of Radiology, Yüksek İhtisas University Medical Park Ankara Batıkent Hospital, Ankara, TUR., Gençler OS; Department of Neurology, Yüksek İhtisas University Medical Park Ankara Hospital, Ankara, TUR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Apr 03; Vol. 14 (4), pp. e23796. Date of Electronic Publication: 2022 Apr 03 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.23796 |
| Abstrakt: | In glioblastoma multiforme (GBM) cases, the tumor usually remains limited to the central nervous system in the expected disease course. Here, we discuss the case of a 41-year-old male patient who presented with extracranial spread, which has been reported in a limited number of cases in the literature. The patient received six lines of treatment including radiotherapy with temozolomide, irinotecan-bevacizumab combination, lomustine, erlotinib, everolimus, and weekly carboplatin-paclitaxel. In addition to systemic treatment, the patient underwent radiotherapy and surgery twice. Despite presenting with features consistent with a poor prognosis and extensive multi-organ metastasis, the patient achieved an overall survival of 25 months. In our view, the clinical course of our case, the follow-up, and the treatment process will add to the literature. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Aslan et al.) |
| Databáze: | MEDLINE |
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