Fabrication of an (α-Mn 2 O 3 :Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology.

Autor: Abdel-Raoof AM; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University 11751, Nasr City Cairo Egypt Ahmedmeetyazeed79@Azhar.edu.eg Ahmedmeetyazeed79@yahoo.com., Osman AOE; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University 11751, Nasr City Cairo Egypt Ahmedmeetyazeed79@Azhar.edu.eg Ahmedmeetyazeed79@yahoo.com., El-Desouky EA; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University 11751, Nasr City Cairo Egypt Ahmedmeetyazeed79@Azhar.edu.eg Ahmedmeetyazeed79@yahoo.com., Abdel-Fattah A; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University 11751, Nasr City Cairo Egypt Ahmedmeetyazeed79@Azhar.edu.eg Ahmedmeetyazeed79@yahoo.com., Abdul-Kareem RF; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University 11751, Nasr City Cairo Egypt Ahmedmeetyazeed79@Azhar.edu.eg Ahmedmeetyazeed79@yahoo.com., Elgazzar E; Department of Physics, Faculty of Science, Suez Canal University Ismailia Egypt.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2020 Jul 01; Vol. 10 (42), pp. 24985-24993. Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
DOI: 10.1039/d0ra05106c
Abstrakt: A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn 2 O 3 nanostructure on carbon nanotube paste (α-Mn 2 O 3 :Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn 2 O 3 nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn 2 O 3 :Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10 -6 to 1 × 10 -2 mol L -1 at 25 ± °C with a detection limit of 2.84 × 10 -7 mol L -1 . It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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